Expression of CTSD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cathepsin D

Protein class

Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003001	CAB000109

GENE INFORMATION
Gene name	CTSD (HGNC Symbol)
Synonyms	CLN10, CPSD
Description	Cathepsin D (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	1752752 - 1763992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117984 (version 83.38)
Entrez gene	1509
UniProt	P07339 (UniProt - Evidence at protein level)
neXtProt	NX_P07339
Antibodypedia	CTSD antibodies

PROTEIN BROWSER

CTSD-001	CTSD-002	CTSD-004	CTSD-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSD-001 ENSP00000236671 ENST00000236671	P07339 [Direct mapping] Cathepsin D Cathepsin D light chain Cathepsin D heavy chain V9HWI3 [Target identity:100%; Query identity:100%] Cathepsin D (Lysosomal aspartyl peptidase), isoform CRA_a; Epididymis secretory sperm binding protein Li 130P Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006914 [autophagy] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0022617 [extracellular matrix disassembly] GO:0030163 [protein catabolic process] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0042470 [melanosome] GO:0043202 [lysosomal lumen] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] Show all	412 aa 44.6 kDa	Yes	0
CTSD-002 ENSP00000356164 ENST00000367196	F8W787 [Direct mapping] Cathepsin D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0006914 [autophagy] GO:0030163 [protein catabolic process] Show all	199 aa 21.5 kDa	No	0
CTSD-004 ENSP00000402586 ENST00000429746	H7C1V0 [Direct mapping] Cathepsin D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0006914 [autophagy] GO:0030163 [protein catabolic process] Show all	189 aa 20.4 kDa	No	0
CTSD-005 ENSP00000415036 ENST00000438213	C9JH19 [Direct mapping] Cathepsin D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0006914 [autophagy] GO:0030163 [protein catabolic process] Show all	299 aa 32.6 kDa	No	0