Expression of COLEC11 in cancer - Summary

CANCER ATLAS

Gene description

Collectin sub-family member 11

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035241

GENE INFORMATION
Gene name	COLEC11 (HGNC Symbol)
Synonyms	CL-K1, MGC3279
Description	Collectin sub-family member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	3594832 - 3644644
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118004 (version 83.38)
Entrez gene	78989
UniProt	Q9BWP8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWP8
Antibodypedia	COLEC11 antibodies

PROTEIN BROWSER

COLEC11-001	COLEC11-002	COLEC11-005	COLEC11-006	COLEC11-007	COLEC11-008	COLEC11-009	COLEC11-201	COLEC11-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COLEC11-001 ENSP00000236693 ENST00000236693	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	268 aa 29 kDa	No	0
COLEC11-002 ENSP00000339168 ENST00000349077	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	271 aa 28.7 kDa	Yes	0
COLEC11-005 ENSP00000384882 ENST00000402794	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	221 aa 23.9 kDa	No	0
COLEC11-006 ENSP00000385827 ENST00000404205	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	197 aa 21.6 kDa	No	0
COLEC11-007 ENSP00000385130 ENST00000403096	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	245 aa 26.2 kDa	No	0
COLEC11-008 ENSP00000385653 ENST00000402922	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	221 aa 23.9 kDa	No	0
COLEC11-009 ENSP00000393167 ENST00000438814	C9JWT5 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 12.2 kDa	Yes	0
COLEC11-201 ENSP00000371494 ENST00000382062	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	247 aa 26.3 kDa	Yes	0
COLEC11-202 ENSP00000411770 ENST00000418971	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0032502 [developmental process] Show all	285 aa 30.2 kDa	Yes	0