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TNNT2

GENERAL INFORMATION

Gene name

 TNNT2

Gene description

 Troponin T type 2 (cardiac)

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (heart muscle)
GTEx:Tissue enriched (heart muscle)
FANTOM5:Tissue enriched (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in cardiac myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA015774 , HPA017888 , CAB015371
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION

Gene name

 TNNT2 (HGNC Symbol)

Synonyms

 CMD1D, CMH2, CMPD2

Description

 Troponin T type 2 (cardiac) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 201359008 - 201377762

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118194 (version 83.38)

Entrez gene

 7139

UniProt

 P45379 (UniProt - Evidence at protein level)

neXtProt

 NX_P45379

Antibodypedia

 TNNT2 antibodies

PROTEIN BROWSER
«
TNNT2-001
TNNT2-002
TNNT2-003
TNNT2-005
TNNT2-008
TNNT2-010
TNNT2-012
TNNT2-014
TNNT2-201
TNNT2-202
TNNT2-203
TNNT2-204
TNNT2-205
TNNT2-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNT2-001
ENSP00000356291
ENST00000367322
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0051592 [response to calcium ion]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 285 aa
34.3 kDa 		No 0
TNNT2-002
ENSP00000414036
ENST00000438742
E7EPW4 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
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 271 aa
32.7 kDa 		No 0
TNNT2-003
ENSP00000356289
ENST00000367320
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0051592 [response to calcium ion]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 255 aa
30.7 kDa 		No 0
TNNT2-005
ENSP00000356287
ENST00000367318
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0051592 [response to calcium ion]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 288 aa
34.6 kDa 		No 0
TNNT2-008
ENSP00000422031
ENST00000509001
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0051592 [response to calcium ion]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 288 aa
34.6 kDa 		No 0
TNNT2-010
ENSP00000402238
ENST00000455702
E7EPN8 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 180 aa
21.8 kDa 		No 0
TNNT2-012
ENSP00000408731
ENST00000412633
C9JM61 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 98 aa
11.4 kDa 		No 0
TNNT2-014
ENSP00000395163
ENST00000422165
C9JDF8 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 114 aa
13.5 kDa 		No 0
TNNT2-201
ENSP00000236918
ENST00000236918
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007507 [heart development]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0030674 [protein binding, bridging]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0032972 [regulation of muscle filament sliding speed]
GO:0045214 [sarcomere organization]
GO:0051291 [protein heterooligomerization]
GO:0051592 [response to calcium ion]
GO:0051764 [actin crosslink formation]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 298 aa
35.9 kDa 		No 0
TNNT2-202
ENSP00000353535
ENST00000360372
P45379 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0005865 [striated muscle thin filament]
GO:0008016 [regulation of heart contraction]
GO:0016887 [ATPase activity]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030172 [troponin C binding]
GO:0031013 [troponin I binding]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0051592 [response to calcium ion]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 255 aa
30.7 kDa 		No 0
TNNT2-203
ENSP00000356284
ENST00000367315
A0A0A0MRJ4 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 291 aa
35 kDa 		No 0
TNNT2-204
ENSP00000356286
ENST00000367317
A0A0A0MRJ5 [Direct mapping]
Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 282 aa
34 kDa 		No 0
TNNT2-205
ENSP00000404134
ENST00000421663
Q7Z554 [Direct mapping]
Troponin T cardiac isoform; Troponin T type 2 (Cardiac), isoform CRA_b; Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 226 aa
27.5 kDa 		No 0
TNNT2-206
ENSP00000387874
ENST00000458432
Q7Z554 [Direct mapping]
Troponin T cardiac isoform; Troponin T type 2 (Cardiac), isoform CRA_b; Troponin T, cardiac muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
Show all
 226 aa
27.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.