Cell atlas - DDX59 - The Human Protein Atlas

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DDX59

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleus

Human cell
	Actin Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DDX59
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Actin filaments (approved)
Mouse	Localized to the Actin filaments in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047166
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & actin filaments.

Main location

Nucleus (approved), Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047166	A-431	Nucleus
	HPA047166	A-431	Actin filaments
	HPA047166	MCF7	Nucleus
	HPA047166	MCF7	Actin filaments
	HPA047166	U-2 OS	Nucleus
	HPA047166	U-2 OS	Actin filaments

MOUSE CELLS

Main location

Actin filaments

Additional location

Nucleus

Mouse gene

ENSMUSG00000026404 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA047166	NIH 3T3	Nucleus
	HPA047166	NIH 3T3	Actin filaments

GENE INFORMATION
Gene name	DDX59 (HGNC Symbol)
Synonyms	DKFZP564B1023, ZNHIT5
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	200623896 - 200669969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118197 (version 83.38)
Entrez gene	83479
UniProt	Q5T1V6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T1V6
Antibodypedia	DDX59 antibodies

PROTEIN BROWSER

DDX59-001	DDX59-002	DDX59-003	DDX59-004	DDX59-005	DDX59-006	DDX59-007	DDX59-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX59-001 ENSP00000394367 ENST00000447706	Q5T1V6 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010501 [RNA secondary structure unwinding] GO:0046872 [metal ion binding] Show all	580 aa 64.6 kDa	No	0
DDX59-002 ENSP00000330460 ENST00000331314	Q5T1V6 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010501 [RNA secondary structure unwinding] GO:0046872 [metal ion binding] Show all	619 aa 68.8 kDa	No	0
DDX59-003 ENSP00000408662 ENST00000429498	H0Y6Y1 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	197 aa 22.1 kDa	No	0
DDX59-004 ENSP00000394304 ENST00000413408	Q5T1W1 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] GO:0016021 [integral component of membrane] Show all	205 aa 22.9 kDa	No	0
DDX59-005 ENSP00000398152 ENST00000453944	B7ZBU4 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	75 aa 8.4 kDa	No	0
DDX59-006 ENSP00000409954 ENST00000433235	B7ZBU3 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	224 aa 25 kDa	No	0
DDX59-007 ENSP00000416331 ENST00000452560	H0Y7Z8 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	94 aa 10.5 kDa	No	0
DDX59-008 ENSP00000391312 ENST00000436897	Q5T1V5 [Direct mapping] Probable ATP-dependent RNA helicase DDX59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	161 aa 17.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.