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Cancer cells generally showed strong nuclear positivity. Most hepatocellular carcinomas were negative.
GENE INFORMATION
Gene name
CREB1
Synonyms
Description
CAMP responsive element binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q5U0J5 [Target identity:100%; Query identity:100%] cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_a; cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000790 [nuclear chromatin] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0001666 [response to hypoxia] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007219 [Notch signaling pathway] GO:0007268 [synaptic transmission] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007568 [aging] GO:0007595 [lactation] GO:0007613 [memory] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008361 [regulation of cell size] GO:0008542 [visual learning] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010033 [response to organic substance] GO:0010629 [negative regulation of gene expression] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0014823 [response to activity] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0021983 [pituitary gland development] GO:0030424 [axon] GO:0030544 [Hsp70 protein binding] GO:0030879 [mammary gland development] GO:0032916 [positive regulation of transforming growth factor beta3 production] GO:0033363 [secretory granule organization] GO:0033762 [response to glucagon] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0034670 [chemotaxis to arachidonic acid] GO:0035035 [histone acetyltransferase binding] GO:0035094 [response to nicotine] GO:0035497 [cAMP response element binding] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0036276 [response to antidepressant] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0040018 [positive regulation of multicellular organism growth] GO:0042493 [response to drug] GO:0042752 [regulation of circadian rhythm] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045600 [positive regulation of fat cell differentiation] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046887 [positive regulation of hormone secretion] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048145 [regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0051403 [stress-activated MAPK cascade] GO:0060251 [regulation of glial cell proliferation] GO:0060428 [lung epithelium development] GO:0060430 [lung saccule development] GO:0060509 [Type I pneumocyte differentiation] GO:0071294 [cellular response to zinc ion] GO:0071363 [cellular response to growth factor stimulus] GO:0071398 [cellular response to fatty acid] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1901215 [negative regulation of neuron death] GO:1902065 [response to L-glutamate] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990314 [cellular response to insulin-like growth factor stimulus] GO:1990589 [ATF4-CREB1 transcription factor complex] GO:1990763 [arrestin family protein binding]
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
E7EWP8 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
C9J276 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]
C9JBT4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated]
C9JCI4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J4L5 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
C9J896 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]