Cell atlas - KLF7 - The Human Protein Atlas

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KLF7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	KLF7
Gene description	Kruppel-like factor 7 (ubiquitous)
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at transcript level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA030490
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030490	A-431	Golgi apparatus
	HPA030490	U-2 OS	Golgi apparatus
	HPA030490	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	KLF7 (HGNC Symbol)
Synonyms	UKLF
Description	Kruppel-like factor 7 (ubiquitous) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	2
Cytoband	q33.3
Chromosome location (bp)	207074137 - 207167267
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000118263 (version 83.38)
Entrez gene	8609
UniProt	O75840 (UniProt - Evidence at transcript level)
neXtProt	NX_O75840
Antibodypedia	KLF7 antibodies

PROTEIN BROWSER

KLF7-001	KLF7-002	KLF7-003	KLF7-004	KLF7-006	KLF7-008	KLF7-009	KLF7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLF7-001 ENSP00000309570 ENST00000309446	O75840 [Direct mapping] Krueppel-like factor 7 A0A024R3X8 [Target identity:100%; Query identity:100%] Kruppel-like factor 7 (Ubiquitous), isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0008270 [zinc ion binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048813 [dendrite morphogenesis] Show all	302 aa 33.4 kDa	No	0
KLF7-002 ENSP00000387510 ENST00000421199	O75840 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	269 aa 29.6 kDa	No	0
KLF7-003 ENSP00000398572 ENST00000423015	O75840 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] Show all	230 aa 24.8 kDa	No	0
KLF7-004 ENSP00000392015 ENST00000457962	E7EUU0 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Show all		60 aa 7 kDa	No	0
KLF7-006 ENSP00000397245 ENST00000426163	E7EQY2 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Show all		112 aa 12.8 kDa	No	0
KLF7-008 ENSP00000413590 ENST00000435602	C9JX20 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Show all		175 aa 18.5 kDa	No	0
KLF7-009 ENSP00000393268 ENST00000458272	O75840 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	112 aa 13.4 kDa	No	0
KLF7-201 ENSP00000403284 ENST00000412414	O75840 [Direct mapping] Krueppel-like factor 7 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	274 aa 30.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.