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Rare case of pancreatic cancer displayed strong cytoplasmic staining. Moderate positivity was observed in a case of breast cancer. Remaining cancer tissues were weakly stained or negative.
Several cases of renal-, urothelial-, testicular- and endometrial cancer displayed moderate to strong cytoplasmic immunoreactivity. Stromal cells were distinctly stained. Most other tumor cells were weakly stained or negative.
A single case of renal cancer along with fraction of cells in a single case of papillary adenocarcinoma of thyroid showed moderate cytoplasmic immunoreactivity. All other cancer tissues were negative.
Few cases of carcinoid showed moderate to strong cytoplasmic staining. A subset of tumor cells in a single case each of pancreas and renal cancers displayed strong positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
TTR (HGNC Symbol)
Synonyms
CTS, CTS1, HsT2651, PALB
Description
Transthyretin (HGNC Symbol)
Entrez gene summary
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
