Cell atlas - CA14 - The Human Protein Atlas

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CA14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CA14
Gene description	Carbonic anhydrase XIV
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (SK-MEL-30, AF22, NTERA-2, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008482
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SK-MEL-30, AF22, NTERA-2, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008482	SK-MEL-30	Plasma membrane

GENE INFORMATION
Gene name	CA14
Synonyms
Description	Carbonic anhydrase XIV (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150257159 - 150265078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118298 (version 83.38)
Entrez gene	23632
UniProt	Q9ULX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULX7
Antibodypedia	CA14 antibodies

PROTEIN BROWSER

CA14-001	CA14-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA14-001 ENSP00000358107 ENST00000369111	Q9ULX7 [Direct mapping] Carbonic anhydrase 14 A8K3J4 [Target identity:100%; Query identity:100%] Carbonic anhydrase XIV, isoform CRA_d; cDNA FLJ77981, highly similar to Homo sapiens carbonic anhydrase 14; cDNA, FLJ96529, Homo sapiens carbonic anhydrase XIV (CA14), mRNA Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	337 aa 37.7 kDa	Yes	1
CA14-005 ENSP00000475238 ENST00000607082	U3KPU6 [Direct mapping] Carbonic anhydrase 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.