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PLAGL1

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GENERAL INFORMATION

Gene name

 PLAGL1

Gene description

 Pleiomorphic adenoma gene-like 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the Golgi apparatus & vesicles.

RNA cell category

 Cell line enhanced (AF22, RH-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

Additional location

 In addition localized to the Golgi apparatus (uncertain), Vesicles (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA055706
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the Golgi apparatus & vesicles.

Main location

 Nuclear bodies (supported)

Additional location

 Golgi apparatus (uncertain), Vesicles (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055706 HeLa Nuclear bodies Intensity
Golgi apparatus Intensity
HPA055706 U-2 OS Nuclear bodies
Golgi apparatus Intensity
Vesicles
HPA055706 U-251 MG Nuclear bodies
Golgi apparatus Intensity

GENE INFORMATION

Gene name

 PLAGL1 (HGNC Symbol)

Synonyms

 LOT1, ZAC

Description

 Pleiomorphic adenoma gene-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

Chromosome

 6

Cytoband

 q24.2

Chromosome location (bp)

 143940300 - 144064599

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118495 (version 83.38)

Entrez gene

 5325

UniProt

 Q9UM63 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UM63

Antibodypedia

 PLAGL1 antibodies

PROTEIN BROWSER
«
PLAGL1-001
PLAGL1-002
PLAGL1-003
PLAGL1-004
PLAGL1-005
PLAGL1-010
PLAGL1-011
PLAGL1-012
PLAGL1-015
PLAGL1-016
PLAGL1-017
PLAGL1-018
PLAGL1-201
PLAGL1-202
PLAGL1-203
PLAGL1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLAGL1-001
ENSP00000356543
ENST00000367571
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0
PLAGL1-002
ENSP00000356544
ENST00000367572
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 411 aa
44.7 kDa 		No 0
PLAGL1-003
ENSP00000346810
ENST00000354765
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0
PLAGL1-004
ENSP00000353734
ENST00000360537
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0010468 [regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0
PLAGL1-005
ENSP00000395960
ENST00000417959
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 411 aa
44.7 kDa 		No 0
PLAGL1-010
ENSP00000486763
ENST00000629195
A1YLA1 [Direct mapping]
Pleiomorphic adenoma gene-like protein 1; Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 64 aa
7.5 kDa 		No 0
PLAGL1-011
ENSP00000486355
ENST00000625622
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0
PLAGL1-012
ENSP00000486711
ENST00000626373
A1YLA2 [Direct mapping]
Pleiomorphic adenoma gene-like protein 1; Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0030154 [cell differentiation]
Show all
 12 aa
1.4 kDa 		No 0
PLAGL1-015
ENSP00000486752
ENST00000626462
A0A0D9SFM8 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 75 aa
8.4 kDa 		No 0
PLAGL1-016
ENSP00000486632
ENST00000628651
A0A0D9SFI7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 102 aa
11.3 kDa 		No 0
PLAGL1-017
ENSP00000485907
ENST00000627449
A0A0D9SEQ4 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 73 aa
8.2 kDa 		No 0
PLAGL1-018
ENSP00000487447
ENST00000626294
A0A0D9SGF7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 80 aa
8.9 kDa 		No 0
PLAGL1-201
ENSP00000376124
ENST00000392307
Q68DN7 [Direct mapping]
Putative uncharacterized protein DKFZp781P1017; Zinc finger protein PLAGL1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
Show all
 252 aa
26.4 kDa 		No 0
PLAGL1-202
ENSP00000400060
ENST00000416623
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0
PLAGL1-203
ENSP00000392418
ENST00000437412
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 411 aa
44.7 kDa 		No 0
PLAGL1-204
ENSP00000400929
ENST00000444202
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0030154 [cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 463 aa
50.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.