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MYB

GENERAL INFORMATION

Gene name

 MYB

Gene description

 V-myb avian myeloblastosis viral oncogene homolog

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum, breast)
GTEx:Tissue enhanced (breast, colon)
FANTOM5:Tissue enhanced (colon, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression in several different tissue types, including gastrointestinal tract and lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB017704
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum, breast)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin051015202530TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (breast, colon)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, appendix)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina051015202530Tags Per Million

GENE INFORMATION

Gene name

 MYB (HGNC Symbol)

Synonyms

 c-myb

Description

 V-myb avian myeloblastosis viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 135181315 - 135219173

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118513 (version 83.38)

Entrez gene

 4602

UniProt

 P10242 (UniProt - Evidence at protein level)

neXtProt

 NX_P10242

Antibodypedia

 MYB antibodies

PROTEIN BROWSER
«
MYB-001
MYB-002
MYB-004
MYB-005
MYB-009
MYB-014
MYB-017
MYB-021
MYB-038
MYB-039
MYB-041
MYB-201
MYB-202
MYB-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYB-001
ENSP00000356788
ENST00000367814
P10242 [Direct mapping]
Transcriptional activator Myb
Q708E9 [Target identity:100%; Query identity:100%]
C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS; V-myb myeloblastosis viral oncogene homolog (Avian); V-myb myeloblastosis viral oncogene homolog (Avian), isoform CRA_f
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 640 aa
72.3 kDa 		No 0
MYB-002
ENSP00000339992
ENST00000341911
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0010468 [regulation of gene expression]
GO:0016363 [nuclear matrix]
GO:0017145 [stem cell division]
GO:0030099 [myeloid cell differentiation]
GO:0030183 [B cell differentiation]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048566 [embryonic digestive tract development]
GO:0048872 [homeostasis of number of cells]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
GO:0071354 [cellular response to interleukin-6]
GO:0071987 [WD40-repeat domain binding]
Show all
 761 aa
85.5 kDa 		No 0
MYB-004
ENSP00000390460
ENST00000430686
A0A0C4DG19 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 277 aa
32 kDa 		No 0
MYB-005
ENSP00000403387
ENST00000420123
E9PMQ0 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 299 aa
34.7 kDa 		No 0
MYB-009
ENSP00000410825
ENST00000442647
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 637 aa
72 kDa 		No 0
MYB-014
ENSP00000435938
ENST00000525369
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 555 aa
63.2 kDa 		No 0
MYB-017
ENSP00000435055
ENST00000534044
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 603 aa
68.3 kDa 		No 0
MYB-021
ENSP00000436605
ENST00000533624
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 605 aa
68.1 kDa 		No 0
MYB-038
ENSP00000434723
ENST00000528774
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 758 aa
85.2 kDa 		No 0
MYB-039
ENSP00000432851
ENST00000534121
P10242 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0016363 [nuclear matrix]
GO:0045624 [positive regulation of T-helper cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
Show all
 745 aa
83.6 kDa 		No 0
MYB-041
ENSP00000433227
ENST00000527615
E9PLN0 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 611 aa
69.1 kDa 		No 0
MYB-201
ENSP00000326328
ENST00000316528
F8W8G5 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 726 aa
81.8 kDa 		No 0
MYB-202
ENSP00000477898
ENST00000616088
A0A087WTI6 [Direct mapping]
Transcriptional activator Myb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 660 aa
74.6 kDa 		No 0
MYB-203
ENSP00000479896
ENST00000618728
Q708E1 [Direct mapping]
C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS; Transcriptional activator Myb; V-myb myeloblastosis viral oncogene homolog (Avian), isoform CRA_d; V-myb myeloblastosis viral oncogene homologue (Avian)
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 612 aa
69.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.