Tissue expression of SLC16A7 - Summary - The Human Protein Atlas

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SLC16A7

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC16A7
Gene description	Solute carrier family 16 (monocarboxylate transporter), member 7
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA005911
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC16A7 (HGNC Symbol)
Synonyms	MCT2
Description	Solute carrier family 16 (monocarboxylate transporter), member 7 (HGNC Symbol)
Entrez gene summary	This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	59596067 - 59789855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118596 (version 83.38)
Entrez gene	9194
UniProt	O60669 (UniProt - Evidence at protein level)
neXtProt	NX_O60669
Antibodypedia	SLC16A7 antibodies

PROTEIN BROWSER

SLC16A7-001	SLC16A7-002	SLC16A7-003	SLC16A7-004	SLC16A7-005	SLC16A7-008	SLC16A7-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A7-001 ENSP00000261187 ENST00000261187	O60669 [Direct mapping] Monocarboxylate transporter 2 A0A024RBB2 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 7, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005477 [pyruvate secondary active transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035873 [lactate transmembrane transport] GO:0035879 [plasma membrane lactate transport] GO:0050833 [pyruvate transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	478 aa 52.2 kDa	No	>9
SLC16A7-002 ENSP00000449547 ENST00000552432	O60669 [Direct mapping] Monocarboxylate transporter 2 A0A024RBB2 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 7, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005477 [pyruvate secondary active transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035873 [lactate transmembrane transport] GO:0035879 [plasma membrane lactate transport] GO:0050833 [pyruvate transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	478 aa 52.2 kDa	No	>9
SLC16A7-003 ENSP00000448071 ENST00000547379	O60669 [Direct mapping] Monocarboxylate transporter 2 A0A024RBB2 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 7, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005477 [pyruvate secondary active transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035873 [lactate transmembrane transport] GO:0035879 [plasma membrane lactate transport] GO:0050833 [pyruvate transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	478 aa 52.2 kDa	No	>9
SLC16A7-004 ENSP00000448742 ENST00000552024	O60669 [Direct mapping] Monocarboxylate transporter 2 A0A024RBB2 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 7, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005477 [pyruvate secondary active transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035873 [lactate transmembrane transport] GO:0035879 [plasma membrane lactate transport] GO:0050833 [pyruvate transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	478 aa 52.2 kDa	No	>9
SLC16A7-005 ENSP00000446722 ENST00000548610	F8W0N3 [Direct mapping] Monocarboxylate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	435 aa 47.3 kDa	No	>9
SLC16A7-008 ENSP00000447555 ENST00000549465	F8W0U4 [Direct mapping] Monocarboxylate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0035879 [plasma membrane lactate transport] GO:1901475 [pyruvate transmembrane transport] Show all	78 aa 8.7 kDa	No	2
SLC16A7-010 ENSP00000447814 ENST00000548444	F8VS95 [Direct mapping] Monocarboxylate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] GO:1901475 [pyruvate transmembrane transport] Show all	131 aa 14.5 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.