Expression of MYL12B in cancer - Summary

CANCER ATLAS

Gene description

Myosin, light chain 12B, regulatory

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039262	HPA045244	HPA059197

GENE INFORMATION
Gene name	MYL12B (HGNC Symbol)
Synonyms	MRLC2
Description	Myosin, light chain 12B, regulatory (HGNC Symbol)
Entrez gene summary	The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Chromosome	18
Cytoband	p11.31
Chromosome location (bp)	3261909 - 3278284
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118680 (version 83.38)
Entrez gene	103910
UniProt	O14950 (UniProt - Evidence at protein level)
neXtProt	NX_O14950
Antibodypedia	MYL12B antibodies

PROTEIN BROWSER

MYL12B-001	MYL12B-002	MYL12B-003	MYL12B-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL12B-001 ENSP00000237500 ENST00000237500	O14950 [Direct mapping] Myosin regulatory light chain 12B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	172 aa 19.8 kDa	No	0
MYL12B-002 ENSP00000463559 ENST00000581193	O14950 [Direct mapping] Myosin regulatory light chain 12B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0006936 [muscle contraction] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0008360 [regulation of cell shape] GO:0016460 [myosin II complex] GO:0030018 [Z disc] GO:0032036 [myosin heavy chain binding] GO:0043234 [protein complex] GO:0045177 [apical part of cell] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	172 aa 19.8 kDa	No	0
MYL12B-003 ENSP00000383037 ENST00000400175	O14950 [Direct mapping] Myosin regulatory light chain 12B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	172 aa 19.8 kDa	No	0
MYL12B-004 ENSP00000464464 ENST00000584539	O14950 [Direct mapping] Myosin regulatory light chain 12B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	172 aa 19.8 kDa	No	0