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Most malignancies showed moderate to strong nuclear positivity.
GENE INFORMATION
Gene name
FOXO3 (HGNC Symbol)
Synonyms
AF6q21, FKHRL1, FOXO2, FOXO3A
Description
Forkhead box O3 (HGNC Symbol)
Entrez gene summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0031490 [chromatin DNA binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034599 [cellular response to oxidative stress] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001221 [transcription cofactor binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001542 [ovulation from ovarian follicle] GO:0001544 [initiation of primordial ovarian follicle growth] GO:0001547 [antral ovarian follicle growth] GO:0001556 [oocyte maturation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0031490 [chromatin DNA binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034599 [cellular response to oxidative stress] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097150 [neuronal stem cell population maintenance] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000177 [regulation of neural precursor cell proliferation] GO:2000377 [regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0019901 [protein kinase binding] GO:0030154 [cell differentiation] GO:0031490 [chromatin DNA binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034599 [cellular response to oxidative stress] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]