Cell atlas - TGIF2 - The Human Protein Atlas

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TGIF2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TGIF2
Gene description	TGFB-induced factor homeobox 2
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA053786
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053786	CACO-2	Nucleoplasm
	HPA053786	MCF7	Nucleoplasm
	HPA053786	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000062175 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053786	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	TGIF2
Synonyms
Description	TGFB-induced factor homeobox 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36573488 - 36593950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118707 (version 83.38)
Entrez gene	60436
UniProt	Q9GZN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZN2
Antibodypedia	TGIF2 antibodies

PROTEIN BROWSER

TGIF2-001	TGIF2-002	TGIF2-003	TGIF2-004	TGIF2-005	TGIF2-006	TGIF2-007	TGIF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGIF2-001 ENSP00000362979 ENST00000373872	Q9GZN2 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010467 [gene expression] Show all	237 aa 25.9 kDa	No	0
TGIF2-002 ENSP00000362981 ENST00000373874	Q9GZN2 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0045666 [positive regulation of neuron differentiation] GO:0060041 [retina development in camera-type eye] Show all	237 aa 25.9 kDa	No	0
TGIF2-003 ENSP00000453773 ENST00000560025	Q9GZN2 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010467 [gene expression] Show all	237 aa 25.9 kDa	No	0
TGIF2-004 ENSP00000452878 ENST00000558028	H0YKN5 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] Show all	174 aa 18.9 kDa	No	0
TGIF2-005 ENSP00000475729 ENST00000561398	U3KQB5 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	92 aa 10.2 kDa	No	0
TGIF2-006 ENSP00000476174 ENST00000557885	U3KQS0 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	111 aa 13 kDa	No	0
TGIF2-007 ENSP00000475479 ENST00000558465	U3KQ25 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Show all		35 aa 3.7 kDa	No	0
TGIF2-201 ENSP00000481787 ENST00000611732	Q9GZN2 [Direct mapping] Homeobox protein TGIF2 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010467 [gene expression] Show all	237 aa 25.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.