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Gene name

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Chromosome

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Reliability

Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

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Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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PKD2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PKD2

Gene description

Polycystic kidney disease 2 (autosomal dominant)

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA015794 , CAB004544
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PKD2 (HGNC Symbol)

Synonyms

Pc-2, PC2, PKD4, TRPP2

Description

Polycystic kidney disease 2 (autosomal dominant) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]

Chromosome

4

Cytoband

q22.1

Chromosome location (bp)

88007668 - 88077777

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118762 (version 83.38)

Entrez gene

5311

UniProt

Q13563 (UniProt - Evidence at protein level)

neXtProt

NX_Q13563

Antibodypedia

PKD2 antibodies

PROTEIN BROWSER

PKD2-001
PKD2-002
PKD2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKD2-001
ENSP00000237596
ENST00000237596
Q13563 [Direct mapping]
Polycystin-2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001892 [embryonic placenta development]
GO:0001947 [heart looping]
GO:0002133 [polycystin complex]
GO:0003127 [detection of nodal flow]
GO:0005102 [receptor binding]
GO:0005244 [voltage-gated ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005929 [cilium]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007050 [cell cycle arrest]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007259 [JAK-STAT cascade]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008092 [cytoskeletal protein binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0021510 [spinal cord development]
GO:0021915 [neural tube development]
GO:0022843 [voltage-gated cation channel activity]
GO:0030027 [lamellipodium]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031512 [motile primary cilium]
GO:0031513 [nonmotile primary cilium]
GO:0031587 [positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031941 [filamentous actin]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035502 [metanephric part of ureteric bud development]
GO:0035725 [sodium ion transmembrane transport]
GO:0035904 [aorta development]
GO:0036064 [ciliary basal body]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042805 [actinin binding]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043398 [HLH domain binding]
GO:0044325 [ion channel binding]
GO:0045180 [basal cortex]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048763 [calcium-induced calcium release activity]
GO:0050982 [detection of mechanical stimulus]
GO:0051117 [ATPase binding]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051219 [phosphoprotein binding]
GO:0051298 [centrosome duplication]
GO:0051371 [muscle alpha-actinin binding]
GO:0051393 [alpha-actinin binding]
GO:0060170 [ciliary membrane]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060674 [placenta blood vessel development]
GO:0061333 [renal tubule morphogenesis]
GO:0061441 [renal artery morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane]
GO:0071464 [cellular response to hydrostatic pressure]
GO:0071470 [cellular response to osmotic stress]
GO:0071498 [cellular response to fluid shear stress]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:0071910 [determination of liver left/right asymmetry]
GO:0072001 [renal system development]
GO:0072075 [metanephric mesenchyme development]
GO:0072164 [mesonephric tubule development]
GO:0072177 [mesonephric duct development]
GO:0072208 [metanephric smooth muscle tissue development]
GO:0072214 [metanephric cortex development]
GO:0072218 [metanephric ascending thin limb development]
GO:0072219 [metanephric cortical collecting duct development]
GO:0072235 [metanephric distal tubule development]
GO:0072284 [metanephric S-shaped body morphogenesis]
GO:0072686 [mitotic spindle]
GO:0090279 [regulation of calcium ion import]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
968 aa
109.7 kDa
No 7
PKD2-002
ENSP00000427131
ENST00000508588
B4DFN3 [Direct mapping]
Polycystin-2; cDNA FLJ50473, highly similar to Polycystin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0016021 [integral component of membrane]
GO:0050982 [detection of mechanical stimulus]
Show all
386 aa
43.9 kDa
No 2
PKD2-005
ENSP00000425289
ENST00000502363
B4DFN3 [Direct mapping]
Polycystin-2; cDNA FLJ50473, highly similar to Polycystin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0016021 [integral component of membrane]
GO:0050982 [detection of mechanical stimulus]
Show all
386 aa
43.9 kDa
No 2

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