Fields »
ABOUT
HELP
BLOG
SPP1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 SPP1

Gene description

 Secreted phosphoprotein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus.

RNA cell category

 Group enriched (RPTEC TERT1, EFO-21, Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA027540
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, EFO-21, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus.

Main location

 Golgi apparatus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA027540 A549 No staining    
HPA027540 Hep G2 Golgi apparatus
HPA027540 U-2 OS No staining    

GENE INFORMATION

Gene name

 SPP1 (HGNC Symbol)

Synonyms

 BNSP, BSPI, ETA-1, OPN

Description

 Secreted phosphoprotein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 87975650 - 87983426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118785 (version 83.38)

Entrez gene

 6696

UniProt

 P10451 (UniProt - Evidence at protein level)

neXtProt

 NX_P10451

Antibodypedia

 SPP1 antibodies

PROTEIN BROWSER
SPP1-001
SPP1-002
SPP1-003
SPP1-010
SPP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPP1-001
ENSP00000378517
ENST00000395080
P10451 [Direct mapping]
Osteopontin
A0A024RDE2 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0010033 [response to organic substance]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030593 [neutrophil chemotaxis]
GO:0031214 [biomineral tissue development]
GO:0031988 [membrane-bounded vesicle]
GO:0033280 [response to vitamin D]
GO:0042995 [cell projection]
GO:0045177 [apical part of cell]
GO:0045780 [positive regulation of bone resorption]
GO:0046697 [decidualization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048545 [response to steroid hormone]
GO:0048685 [negative regulation of collateral sprouting of intact axon in response to injury]
GO:0050840 [extracellular matrix binding]
GO:0070062 [extracellular exosome]
GO:0071498 [cellular response to fluid shear stress]
Show all
 314 aa
35.4 kDa 		Yes 0
SPP1-002
ENSP00000237623
ENST00000237623
P10451 [Direct mapping]
Osteopontin
A0A024RDE6 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_c
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 300 aa
33.8 kDa 		Yes 0
SPP1-003
ENSP00000354042
ENST00000360804
P10451 [Direct mapping]
Osteopontin
A0A024RDJ0 [Target identity:100%; Query identity:100%]
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 287 aa
32.4 kDa 		Yes 0
SPP1-010
ENSP00000422973
ENST00000508233
D6R9C5 [Direct mapping]
Osteopontin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0007155 [cell adhesion]
Show all
 241 aa
27.1 kDa 		Yes 0
SPP1-201
ENSP00000477824
ENST00000614857
P10451 [Direct mapping]
Osteopontin
F2YQ21 [Target identity:100%; Query identity:100%]
Osteopontin-D
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007566 [embryo implantation]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0033280 [response to vitamin D]
GO:0046697 [decidualization]
GO:0070062 [extracellular exosome]
Show all
 292 aa
33 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.