Expression of RARRES1 in cancer - Summary

CANCER ATLAS

Gene description

Retinoic acid receptor responder (tazarotene induced) 1

Protein class

Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003892

GENE INFORMATION
Gene name	RARRES1 (HGNC Symbol)
Synonyms	LXNL, TIG1
Description	Retinoic acid receptor responder (tazarotene induced) 1 (HGNC Symbol)
Entrez gene summary	This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.32
Chromosome location (bp)	158696892 - 158732696
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118849 (version 83.38)
Entrez gene	5918
UniProt	P49788 (UniProt - Evidence at protein level)
neXtProt	NX_P49788
Antibodypedia	RARRES1 antibodies

PROTEIN BROWSER

RARRES1-001	RARRES1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RARRES1-001 ENSP00000237696 ENST00000237696	P49788 [Direct mapping] Retinoic acid receptor responder protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	294 aa 33.3 kDa	Yes	0
RARRES1-002 ENSP00000418556 ENST00000479756	P49788 [Direct mapping] Retinoic acid receptor responder protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	228 aa 25.8 kDa	Yes	0