Expression of WDR35 in cancer - Summary

CANCER ATLAS

Gene description

WD repeat domain 35

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044147

GENE INFORMATION
Gene name	WDR35 (HGNC Symbol)
Synonyms	IFT121, IFTA1, KIAA1336, MGC33196
Description	WD repeat domain 35 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Chromosome	2
Cytoband	p24.1
Chromosome location (bp)	19910260 - 19990131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118965 (version 83.38)
Entrez gene	57539
UniProt	Q9P2L0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2L0
Antibodypedia	WDR35 antibodies

PROTEIN BROWSER

WDR35-001	WDR35-002	WDR35-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR35-001 ENSP00000314444 ENST00000345530	Q9P2L0 [Direct mapping] WD repeat-containing protein 35 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005929 [cilium] GO:0005930 [axoneme] GO:0006996 [organelle organization] GO:0030991 [intraciliary transport particle A] GO:0035091 [phosphatidylinositol binding] GO:0035721 [intraciliary retrograde transport] GO:0036064 [ciliary basal body] GO:0042384 [cilium assembly] GO:0061512 [protein localization to cilium] GO:0072372 [primary cilium] GO:0097542 [ciliary tip] Show all	1181 aa 133.5 kDa	No	0
WDR35-002 ENSP00000281405 ENST00000281405	Q9P2L0 [Direct mapping] WD repeat-containing protein 35 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005929 [cilium] GO:0005930 [axoneme] GO:0006996 [organelle organization] GO:0030991 [intraciliary transport particle A] GO:0035091 [phosphatidylinositol binding] GO:0035721 [intraciliary retrograde transport] GO:0036064 [ciliary basal body] GO:0042384 [cilium assembly] GO:0061512 [protein localization to cilium] GO:0072372 [primary cilium] GO:0097542 [ciliary tip] Show all	1170 aa 132.3 kDa	No	0
WDR35-005 ENSP00000404409 ENST00000453014	H0Y6C0 [Direct mapping] WD repeat-containing protein 35 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	406 aa 46.8 kDa	No	0