Expression of NDUFB3 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034596

GENE INFORMATION
Gene name	NDUFB3 (HGNC Symbol)
Synonyms	B12
Description	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa (HGNC Symbol)
Entrez gene summary	This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	201071433 - 201085750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119013 (version 83.38)
Entrez gene	4709
UniProt	O43676 (UniProt - Evidence at protein level)
neXtProt	NX_O43676
Antibodypedia	NDUFB3 antibodies

PROTEIN BROWSER

NDUFB3-001	NDUFB3-002	NDUFB3-003	NDUFB3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFB3-001 ENSP00000237889 ENST00000237889	O43676 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 A0A024R413 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 3, 12kDa, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0016021 [integral component of membrane] GO:0022900 [electron transport chain] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	98 aa 11.4 kDa	No	1
NDUFB3-002 ENSP00000401834 ENST00000450023	C9JKQ2 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0022900 [electron transport chain] Show all	65 aa 7.6 kDa	No	0
NDUFB3-003 ENSP00000410600 ENST00000433898	O43676 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 A0A024R413 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 3, 12kDa, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0016021 [integral component of membrane] GO:0022900 [electron transport chain] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	98 aa 11.4 kDa	No	1
NDUFB3-004 ENSP00000407336 ENST00000454214	O43676 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 A0A024R413 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 3, 12kDa, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0016021 [integral component of membrane] GO:0022900 [electron transport chain] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	98 aa 11.4 kDa	No	1