Cell atlas - GTF3C3 - The Human Protein Atlas

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GTF3C3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GTF3C3
Gene description	General transcription factor IIIC, polypeptide 3, 102kDa
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA069179
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nuclear membrane.

Main location

Nucleus (supported), Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA069179	HeLa	Nucleus
			Nuclear membrane
			Nucleoli
	HPA069179	SH-SY5Y	Nucleoplasm
	HPA069179	SH-SY5Y	Nuclear membrane
	HPA069179	U-2 OS	Nucleoplasm
	HPA069179	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	GTF3C3 (HGNC Symbol)
Synonyms	TFIIIC102, TFiiiC2-102
Description	General transcription factor IIIC, polypeptide 3, 102kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	196763032 - 196799725
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119041 (version 83.38)
Entrez gene	9330
UniProt	Q9Y5Q9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Q9
Antibodypedia	GTF3C3 antibodies

PROTEIN BROWSER

GTF3C3-001	GTF3C3-002	GTF3C3-003	GTF3C3-004	GTF3C3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTF3C3-001 ENSP00000263956 ENST00000263956	Q9Y5Q9 [Direct mapping] General transcription factor 3C polypeptide 3 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000127 [transcription factor TFIIIC complex] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0010467 [gene expression] GO:0042791 [5S class rRNA transcription from RNA polymerase III type 1 promoter] GO:0042797 [tRNA transcription from RNA polymerase III promoter] Show all	886 aa 101.3 kDa	No	0
GTF3C3-002 ENSP00000398385 ENST00000448087	H7C143 [Direct mapping] General transcription factor 3C polypeptide 3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.9 kDa	No	0
GTF3C3-003 ENSP00000394065 ENST00000435252	H7C0C0 [Direct mapping] General transcription factor 3C polypeptide 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.6 kDa	No	1
GTF3C3-004 ENSP00000386465 ENST00000409364	Q9Y5Q9 [Direct mapping] General transcription factor 3C polypeptide 3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000127 [transcription factor TFIIIC complex] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0010467 [gene expression] GO:0042791 [5S class rRNA transcription from RNA polymerase III type 1 promoter] GO:0042797 [tRNA transcription from RNA polymerase III promoter] Show all	413 aa 47.3 kDa	No	0
GTF3C3-006 ENSP00000391724 ENST00000416690	H7BZV8 [Direct mapping] General transcription factor 3C polypeptide 3 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.