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UBE2B

GENERAL INFORMATION

Gene name

 UBE2B

Gene description

 Ubiquitin-conjugating enzyme E2B

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2B (HGNC Symbol)

Synonyms

 HHR6B, RAD6B, UBC2

Description

 Ubiquitin-conjugating enzyme E2B (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 134371179 - 134391992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119048 (version 83.38)

Entrez gene

 7320

UniProt

 P63146 (UniProt - Evidence at protein level)

neXtProt

 NX_P63146

Antibodypedia

 UBE2B antibodies

PROTEIN BROWSER
UBE2B-001
UBE2B-005
UBE2B-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2B-001
ENSP00000265339
ENST00000265339
P63146 [Direct mapping]
Ubiquitin-conjugating enzyme E2 B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001701 [in utero embryonic development]
GO:0001741 [XY body]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006344 [maintenance of chromatin silencing]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007283 [spermatogenesis]
GO:0007288 [sperm axoneme assembly]
GO:0009411 [response to UV]
GO:0010845 [positive regulation of reciprocal meiotic recombination]
GO:0016567 [protein ubiquitination]
GO:0019985 [translesion synthesis]
GO:0031056 [regulation of histone modification]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033128 [negative regulation of histone phosphorylation]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0042493 [response to drug]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045141 [meiotic telomere clustering]
GO:0050821 [protein stabilization]
GO:0051026 [chiasma assembly]
GO:0051865 [protein autoubiquitination]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070076 [histone lysine demethylation]
GO:0070193 [synaptonemal complex organization]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 152 aa
17.3 kDa 		No 0
UBE2B-005
ENSP00000426364
ENST00000506787
H0YA80 [Direct mapping]
Ubiquitin-conjugating enzyme E2 B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005524 [ATP binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 138 aa
15.4 kDa 		No 0
UBE2B-008
ENSP00000425137
ENST00000507277
H0Y9V2 [Direct mapping]
Ubiquitin-conjugating enzyme E2 B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0016567 [protein ubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 141 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.