Tissue expression of TRPM6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRPM6
Gene description	Transient receptor potential cation channel, subfamily M, member 6
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (rectum, colon)
GTEx:	Tissue enhanced (colon)
FANTOM5:	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (rectum, colon)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION
Gene name	TRPM6 (HGNC Symbol)
Synonyms	CHAK2, FLJ22628, HOMG, HSH
Description	Transient receptor potential cation channel, subfamily M, member 6 (HGNC Symbol)
Entrez gene summary	This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	74722495 - 74888094
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119121 (version 83.38)
Entrez gene	140803
UniProt	Q9BX84 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BX84
Antibodypedia	TRPM6 antibodies

PROTEIN BROWSER

TRPM6-001	TRPM6-002	TRPM6-201	TRPM6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM6-001 ENSP00000354006 ENST00000360774	Q9BX84 [Direct mapping] Transient receptor potential cation channel subfamily M member 6 Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030001 [metal ion transport] GO:0031526 [brush border membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2022 aa 231.7 kDa	No	7
TRPM6-002 ENSP00000351942 ENST00000359047	Q96LV9 [Direct mapping] Transient receptor potential cation channel subfamily M member 6; Transient receptor potential cation channel, subfamily M, member 6, isoform CRA_j; cDNA FLJ25019 fis, clone CBL01642 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005261 [cation channel activity] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0098655 [cation transmembrane transport] Show all	303 aa 34.3 kDa	No	0
TRPM6-201 ENSP00000354962 ENST00000361255	Q9BX84 [Direct mapping] Transient receptor potential cation channel subfamily M member 6 Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2017 aa 231 kDa	No	7
TRPM6-202 ENSP00000396672 ENST00000449912	Q9BX84 [Direct mapping] Transient receptor potential cation channel subfamily M member 6 Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0009636 [response to toxic substance] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2017 aa 231 kDa	No	7