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ITGB1BP1

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GENERAL INFORMATION

Gene name

 ITGB1BP1

Gene description

 Integrin beta 1 binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA071538
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA071538 BJ Nucleoplasm
Cytosol
HPA071538 SK-MEL-30 Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 ITGB1BP1 (HGNC Symbol)

Synonyms

 ICAP-1A, ICAP-1alpha, ICAP-1B, ICAP1, ICAP1A, ICAP1B

Description

 Integrin beta 1 binding protein 1 (HGNC Symbol)

Entrez gene summary

 The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 9403475 - 9423547

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119185 (version 83.38)

Entrez gene

 9270

UniProt

 O14713 (UniProt - Evidence at protein level)

neXtProt

 NX_O14713

Antibodypedia

 ITGB1BP1 antibodies

PROTEIN BROWSER
«
ITGB1BP1-001
ITGB1BP1-002
ITGB1BP1-004
ITGB1BP1-005
ITGB1BP1-009
ITGB1BP1-011
ITGB1BP1-012
ITGB1BP1-013
ITGB1BP1-014
ITGB1BP1-015
ITGB1BP1-016
ITGB1BP1-018
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITGB1BP1-001
ENSP00000347504
ENST00000355346
O14713 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008565 [protein transporter activity]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032403 [protein complex binding]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050880 [regulation of blood vessel size]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 200 aa
21.8 kDa 		No 0
ITGB1BP1-002
ENSP00000238091
ENST00000238091
O14713 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008565 [protein transporter activity]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032403 [protein complex binding]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050880 [regulation of blood vessel size]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 150 aa
16.1 kDa 		No 0
ITGB1BP1-004
ENSP00000352743
ENST00000359712
A8MPU2 [Direct mapping]
Integrin beta 1 binding protein 1, isoform CRA_g; Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 184 aa
20.2 kDa 		No 0
ITGB1BP1-005
ENSP00000353850
ENST00000360635
O14713 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008565 [protein transporter activity]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032403 [protein complex binding]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050880 [regulation of blood vessel size]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 200 aa
21.8 kDa 		No 0
ITGB1BP1-009
ENSP00000419524
ENST00000488451
O14713 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008565 [protein transporter activity]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032403 [protein complex binding]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050880 [regulation of blood vessel size]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 150 aa
16.1 kDa 		No 0
ITGB1BP1-011
ENSP00000389704
ENST00000456913
A8MPU2 [Direct mapping]
Integrin beta 1 binding protein 1, isoform CRA_g; Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 184 aa
20.2 kDa 		No 0
ITGB1BP1-012
ENSP00000418526
ENST00000484735
C9J0J6 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.1 kDa 		No 0
ITGB1BP1-013
ENSP00000417940
ENST00000494563
C9J5T5 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.2 kDa 		No 0
ITGB1BP1-014
ENSP00000419814
ENST00000467606
C9JZ07 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 96 aa
10.2 kDa 		No 0
ITGB1BP1-015
ENSP00000418947
ENST00000497105
C9IZZ8 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
6.9 kDa 		No 0
ITGB1BP1-016
ENSP00000417850
ENST00000460001
C9J6Y2 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
8.9 kDa 		No 0
ITGB1BP1-018
ENSP00000420770
ENST00000492079
C9JBU8 [Direct mapping]
Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
14.8 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.