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Cleavage and polyadenylation specific factor 3, 73kDa (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Q9UKF6 [Direct mapping] Cleavage and polyadenylation specificity factor subunit 3
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome] GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006378 [mRNA polyadenylation] GO:0006379 [mRNA cleavage] GO:0006398 [histone mRNA 3'-end processing] GO:0006406 [mRNA export from nucleus] GO:0008380 [RNA splicing] GO:0008409 [5'-3' exonuclease activity] GO:0010467 [gene expression] GO:0030529 [ribonucleoprotein complex] GO:0031124 [mRNA 3'-end processing] GO:0046872 [metal ion binding] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
