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SET

GENERAL INFORMATION

Gene name

 SET

Gene description

 SET nuclear proto-oncogene

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA063683 , CAB005232
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SET (HGNC Symbol)

Synonyms

 2PP2A, IPP2A2, PHAPII

Description

 SET nuclear proto-oncogene (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128683424 - 128696400

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119335 (version 83.38)

Entrez gene

 6418

UniProt

 Q01105 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01105

Antibodypedia

 SET antibodies

PROTEIN BROWSER
SET-001
SET-002
SET-003
SET-009
SET-010
SET-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SET-001
ENSP00000361777
ENST00000372692
Q01105 [Direct mapping]
Protein SET
Q5VXV3 [Target identity:100%; Query identity:100%]
SET; SET translocation (Myeloid leukemia-associated), isoform CRA_a; cDNA FLJ51749, highly similar to Protein SET
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006334 [nucleosome assembly]
GO:0006337 [nucleosome disassembly]
GO:0006913 [nucleocytoplasmic transport]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035067 [negative regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0043234 [protein complex]
GO:0043488 [regulation of mRNA stability]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
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 290 aa
33.5 kDa 		No 0
SET-002
ENSP00000318012
ENST00000322030
Q01105 [Direct mapping]
Protein SET
A0A024R895 [Target identity:100%; Query identity:100%]
SET translocation (Myeloid leukemia-associated), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006334 [nucleosome assembly]
GO:0006337 [nucleosome disassembly]
GO:0006913 [nucleocytoplasmic transport]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035067 [negative regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0043234 [protein complex]
GO:0043488 [regulation of mRNA stability]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 277 aa
32.1 kDa 		No 0
SET-003
ENSP00000387321
ENST00000409104
Q01105 [Direct mapping]
Protein SET
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006334 [nucleosome assembly]
GO:0006337 [nucleosome disassembly]
GO:0006913 [nucleocytoplasmic transport]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035067 [negative regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0043234 [protein complex]
GO:0043488 [regulation of mRNA stability]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 268 aa
31.3 kDa 		No 0
SET-009
ENSP00000410806
ENST00000454747
B2REB7 [Direct mapping]
Protein SET
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.3 kDa 		No 0
SET-010
ENSP00000361771
ENST00000372686
Q01105 [Direct mapping]
Protein SET
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006334 [nucleosome assembly]
GO:0006337 [nucleosome disassembly]
GO:0006913 [nucleocytoplasmic transport]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035067 [negative regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0043234 [protein complex]
GO:0043488 [regulation of mRNA stability]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 265 aa
31 kDa 		No 0
SET-201
ENSP00000361773
ENST00000372688
A0A0C4DFV9 [Direct mapping]
Protein SET
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006334 [nucleosome assembly]
Show all
 266 aa
31.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.