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PPP2R4

CANCER ATLAS

Gene description

 Protein phosphatase 2A activator, regulatory subunit 4

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005695
CAB022068
CAB035999

GENE INFORMATION

Gene name

 PPP2R4 (HGNC Symbol)

Synonyms

 PR53, PTPA

Description

 Protein phosphatase 2A activator, regulatory subunit 4 (HGNC Symbol)

Entrez gene summary

 Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 129110950 - 129148946

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119383 (version 83.38)

Entrez gene

 5524

UniProt

 Q15257 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15257

Antibodypedia

 PPP2R4 antibodies

PROTEIN BROWSER
«
PPP2R4-001
PPP2R4-002
PPP2R4-003
PPP2R4-004
PPP2R4-005
PPP2R4-006
PPP2R4-007
PPP2R4-009
PPP2R4-010
PPP2R4-011
PPP2R4-012
PPP2R4-013
PPP2R4-014
PPP2R4-015
PPP2R4-016
PPP2R4-017
PPP2R4-018
PPP2R4-019
PPP2R4-020
PPP2R4-021
PPP2R4-022
PPP2R4-023
PPP2R4-024
PPP2R4-201
PPP2R4-202
PPP2R4-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP2R4-001
ENSP00000405100
ENST00000411917
H0Y6E5 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 218 aa
23.9 kDa 		No 0
PPP2R4-002
ENSP00000408316
ENST00000423100
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-003
ENSP00000408726
ENST00000414510
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-004
ENSP00000393196
ENST00000435305
B4DDQ6 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 151 aa
16.1 kDa 		No 0
PPP2R4-005
ENSP00000394001
ENST00000419582
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-006
ENSP00000416661
ENST00000432651
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-007
ENSP00000411604
ENST00000434095
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-009
ENSP00000399069
ENST00000414331
C9IZ76 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 132 aa
14.6 kDa 		No 0
PPP2R4-010
ENSP00000351885
ENST00000358994
Q15257 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016887 [ATPase activity]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0046982 [protein heterodimerization activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070062 [extracellular exosome]
Show all
 323 aa
36.8 kDa 		No 0
PPP2R4-011
ENSP00000377036
ENST00000393370
Q15257 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016887 [ATPase activity]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0046982 [protein heterodimerization activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070062 [extracellular exosome]
Show all
 323 aa
36.8 kDa 		No 0
PPP2R4-012
ENSP00000395499
ENST00000455292
Q5T949 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 250 aa
28.1 kDa 		No 0
PPP2R4-013
ENSP00000406997
ENST00000445241
Q5T948 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 254 aa
28.6 kDa 		No 0
PPP2R4-014
ENSP00000387726
ENST00000435132
B7ZBQ0 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 61 aa
6.9 kDa 		No 0
PPP2R4-015
ENSP00000337412
ENST00000347048
Q68CR8 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 104 aa
11.7 kDa 		No 0
PPP2R4-016
ENSP00000347109
ENST00000355007
Q15257 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016887 [ATPase activity]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0046982 [protein heterodimerization activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070062 [extracellular exosome]
Show all
 281 aa
31.9 kDa 		No 0
PPP2R4-017
ENSP00000403542
ENST00000417728
A6PVN9 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 263 aa
30.2 kDa 		No 0
PPP2R4-018
ENSP00000393092
ENST00000453358
A6PVN8 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 129 aa
14.4 kDa 		No 0
PPP2R4-019
ENSP00000393796
ENST00000440346
A6PVN7 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 64 aa
7.4 kDa 		No 0
PPP2R4-020
ENSP00000335200
ENST00000348141
A6PVN5 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 329 aa
37.4 kDa 		No 0
PPP2R4-021
ENSP00000400314
ENST00000417504
A6PVN6 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 176 aa
19.3 kDa 		No 0
PPP2R4-022
ENSP00000396660
ENST00000455240
H0Y562 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 120 aa
13.9 kDa 		No 0
PPP2R4-023
ENSP00000389312
ENST00000436883
B7ZBP9 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 41 aa
4.6 kDa 		No 0
PPP2R4-024
ENSP00000416522
ENST00000432124
B7ZBP7 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 77 aa
8.4 kDa 		No 0
PPP2R4-201
ENSP00000337448
ENST00000337738
Q15257 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016887 [ATPase activity]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0046982 [protein heterodimerization activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070062 [extracellular exosome]
Show all
 358 aa
40.7 kDa 		No 0
PPP2R4-202
ENSP00000349726
ENST00000357197
Q15257 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016887 [ATPase activity]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0046982 [protein heterodimerization activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070062 [extracellular exosome]
Show all
 294 aa
33.5 kDa 		No 0
PPP2R4-203
ENSP00000394338
ENST00000452489
F6WIT2 [Direct mapping]
Serine/threonine-protein phosphatase 2A activator
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0019211 [phosphatase activator activity]
GO:0030472 [mitotic spindle organization in nucleus]
GO:0043085 [positive regulation of catalytic activity]
Show all
 288 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.