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TRIM32

GENERAL INFORMATION

Gene name

 TRIM32

Gene description

 Tripartite motif containing 32

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA050060
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIM32 (HGNC Symbol)

Synonyms

 BBS11, HT2A, LGMD2H, TATIP

Description

 Tripartite motif containing 32 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q33.1

Chromosome location (bp)

 116687302 - 116701300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119401 (version 83.38)

Entrez gene

 22954

UniProt

 Q13049 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13049

Antibodypedia

 TRIM32 antibodies

PROTEIN BROWSER
TRIM32-001
TRIM32-002
TRIM32-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM32-001
ENSP00000363095
ENST00000373983
Q13049 [Direct mapping]
E3 ubiquitin-protein ligase TRIM32
A0A024R843 [Target identity:100%; Query identity:100%]
Tripartite motif-containing 32, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005863 [striated muscle myosin thick filament]
GO:0008270 [zinc ion binding]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017022 [myosin binding]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030957 [Tat protein binding]
GO:0031369 [translation initiation factor binding]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032897 [negative regulation of viral transcription]
GO:0034612 [response to tumor necrosis factor]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045787 [positive regulation of cell cycle]
GO:0045862 [positive regulation of proteolysis]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:1902187 [negative regulation of viral release from host cell]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000147 [positive regulation of cell motility]
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 653 aa
72 kDa 		No 0
TRIM32-002
ENSP00000412603
ENST00000411410
Q5JVY0 [Direct mapping]
E3 ubiquitin-protein ligase TRIM32
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 173 aa
19.3 kDa 		No 0
TRIM32-201
ENSP00000408292
ENST00000450136
Q13049 [Direct mapping]
E3 ubiquitin-protein ligase TRIM32
A0A024R843 [Target identity:100%; Query identity:100%]
Tripartite motif-containing 32, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0001894 [tissue homeostasis]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005863 [striated muscle myosin thick filament]
GO:0007014 [actin ubiquitination]
GO:0008270 [zinc ion binding]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017022 [myosin binding]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030957 [Tat protein binding]
GO:0031369 [translation initiation factor binding]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032897 [negative regulation of viral transcription]
GO:0034612 [response to tumor necrosis factor]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045787 [positive regulation of cell cycle]
GO:0045862 [positive regulation of proteolysis]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061564 [axon development]
GO:0061630 [ubiquitin protein ligase activity]
GO:1902187 [negative regulation of viral release from host cell]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway]
GO:1903883 [positive regulation of interleukin-17-mediated signaling pathway]
GO:1903886 [positive regulation of chemokine (C-C motif) ligand 20 production]
GO:2000147 [positive regulation of cell motility]
Show all
 653 aa
72 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.