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GALNT12

GENERAL INFORMATION

Gene name

 GALNT12

Gene description

 Polypeptide N-acetylgalactosaminyltransferase 12

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. High expression in the glandular cells of epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA048292
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 GALNT12 (HGNC Symbol)

Synonyms

 GalNAc-T12

Description

 Polypeptide N-acetylgalactosaminyltransferase 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]

Chromosome

 9

Cytoband

 q22.33

Chromosome location (bp)

 98807699 - 98850081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119514 (version 83.38)

Entrez gene

 79695

UniProt

 Q8IXK2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IXK2

Antibodypedia

 GALNT12 antibodies

PROTEIN BROWSER
GALNT12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GALNT12-001
ENSP00000364150
ENST00000375011
Q8IXK2 [Direct mapping]
Polypeptide N-acetylgalactosaminyltransferase 12
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity]
GO:0006493 [protein O-linked glycosylation]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0030246 [carbohydrate binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
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 581 aa
66.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.