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Vacuolar protein sorting 4 homolog B (S. cerevisiae) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
O75351 [Direct mapping] Vacuolar protein sorting-associated protein 4B A0A024R2C5 [Target identity:100%; Query identity:100%] Vacuolar protein sorting 4B (Yeast), isoform CRA_a
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000920 [cell separation after cytokinesis] GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006813 [potassium ion transport] GO:0006997 [nucleus organization] GO:0007032 [endosome organization] GO:0007033 [vacuole organization] GO:0007080 [mitotic metaphase plate congression] GO:0008022 [protein C-terminus binding] GO:0010008 [endosome membrane] GO:0010824 [regulation of centrosome duplication] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0015031 [protein transport] GO:0016032 [viral process] GO:0016197 [endosomal transport] GO:0016887 [ATPase activity] GO:0019058 [viral life cycle] GO:0019076 [viral release from host cell] GO:0030301 [cholesterol transport] GO:0031902 [late endosome membrane] GO:0032510 [endosome to lysosome transport via multivesicular body sorting pathway] GO:0033993 [response to lipid] GO:0039702 [viral budding via host ESCRT complex] GO:0042623 [ATPase activity, coupled] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0048524 [positive regulation of viral process] GO:0050792 [regulation of viral process] GO:0051261 [protein depolymerization] GO:0060548 [negative regulation of cell death] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0090543 [Flemming body] GO:0090611 [ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway] GO:1901673 [regulation of mitotic spindle assembly] GO:1902188 [positive regulation of viral release from host cell] GO:1903542 [negative regulation of exosomal secretion] GO:1903543 [positive regulation of exosomal secretion] GO:1903724 [positive regulation of centriole elongation] GO:1903902 [positive regulation of viral life cycle]
