Expression of PROX2 in cancer - Summary

CANCER ATLAS

Gene description

Prospero homeobox 2

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045057

GENE INFORMATION
Gene name	PROX2 (HGNC Symbol)
Synonyms	FLJ36749
Description	Prospero homeobox 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74852871 - 74871940
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119608 (version 83.38)
Entrez gene	283571
UniProt	Q3B8N5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3B8N5
Antibodypedia	PROX2 antibodies

PROTEIN BROWSER

PROX2-001	PROX2-002	PROX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROX2-001 ENSP00000451463 ENST00000556084	Q3B8N5 [Direct mapping] Prospero homeobox protein 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030182 [neuron differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0055007 [cardiac muscle cell differentiation] Show all	365 aa 40.6 kDa	No	0
PROX2-002 ENSP00000478947 ENST00000619947	A0A0G2JMC2 [Direct mapping] Prospero homeobox protein 2 Show all	Predicted intracellular proteins Show all		8 aa 0.9 kDa	No	0
PROX2-201 ENSP00000451223 ENST00000556489	G3V3G0 [Direct mapping] Prospero homeobox protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] Show all	592 aa 65.6 kDa	No	0