Expression of VSX2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Visual system homeobox 2

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003436

GENE INFORMATION
Gene name	VSX2 (HGNC Symbol)
Synonyms	CHX10, HOX10, RET1
Description	Visual system homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74239472 - 74262738
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119614 (version 83.38)
Entrez gene	338917
UniProt	P58304 (UniProt - Evidence at protein level)
neXtProt	NX_P58304
Antibodypedia	VSX2 antibodies

PROTEIN BROWSER

VSX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VSX2-001 ENSP00000261980 ENST00000261980	P58304 [Direct mapping] Visual system homeobox 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007601 [visual perception] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0045165 [cell fate commitment] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050896 [response to stimulus] GO:0060040 [retinal bipolar neuron differentiation] GO:0060042 [retina morphogenesis in camera-type eye] Show all	361 aa 39.4 kDa	No	0