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ACOT2

GENERAL INFORMATION

Gene name

 ACOT2

Gene description

 Acyl-CoA thioesterase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, including renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA043705
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ACOT2 (HGNC Symbol)

Synonyms

 Mte1, ZAP128

Description

 Acyl-CoA thioesterase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 73567620 - 73575658

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119673 (version 83.38)

Entrez gene

 10965

UniProt

 P49753 (UniProt - Evidence at protein level)

neXtProt

 NX_P49753

Antibodypedia

 ACOT2 antibodies

PROTEIN BROWSER
ACOT2-001
ACOT2-004
ACOT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT2-001
ENSP00000238651
ENST00000238651
P49753 [Direct mapping]
Acyl-coenzyme A thioesterase 2, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0005102 [receptor binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006637 [acyl-CoA metabolic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016790 [thiolester hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.2 kDa 		No 0
ACOT2-004
ENSP00000477685
ENST00000613168
A0A087WT95 [Direct mapping]
Acyl-coenzyme A thioesterase 2, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006637 [acyl-CoA metabolic process]
GO:0016790 [thiolester hydrolase activity]
Show all
 463 aa
50.9 kDa 		No 0
ACOT2-201
ENSP00000483704
ENST00000622407
A0A087X0W7 [Direct mapping]
Acyl-coenzyme A thioesterase 2, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006637 [acyl-CoA metabolic process]
GO:0016790 [thiolester hydrolase activity]
Show all
 421 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.