We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Hepatocellular carcinomas showed strong cytoplasmic immunoreactivity while cases of melanomas, pancreatic, lung and urothelial cancers showed moderate to strong staining. Remaining cancers were in general negative.
Majority of cancer tissue displayed weak cytoplasmic and/or nuclear positivity. Few gliomas and hepatocellular carcinomas displayed strong staining. Lymphomas, renal cell carcinomas along with several cases of stomach, prostate, ovary and endometrial cancers were negative.
GENE INFORMATION
Gene name
PPP4R4 (HGNC Symbol)
Synonyms
CFAP14, KIAA1622, PP4R4
Description
Protein phosphatase 4, regulatory subunit 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The function of this particular gene product has not been determined. Alternative splicing has been observed for this gene and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]