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ESRRB

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GENERAL INFORMATION

Gene name

 ESRRB

Gene description

 Estrogen-related receptor beta

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (K-562, U-266/70, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, U-266/70, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ESRRB (HGNC Symbol)

Synonyms

 DFNB35, ERR2, ERRb, ERRbeta, ESRL2, NR3B2

Description

 Estrogen-related receptor beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 76310614 - 76501841

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119715 (version 83.38)

Entrez gene

 2103

UniProt

 O95718 (UniProt - Evidence at protein level)

neXtProt

 NX_O95718

Antibodypedia

 ESRRB antibodies

PROTEIN BROWSER
ESRRB-002
ESRRB-003
ESRRB-006
ESRRB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESRRB-002
ENSP00000424992
ENST00000512784
E7EWD9 [Direct mapping]
Steroid hormone receptor ERR2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 508 aa
56.2 kDa 		No 0
ESRRB-003
ENSP00000370270
ENST00000380887
O95718 [Direct mapping]
Steroid hormone receptor ERR2
Show all
Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 508 aa
56.2 kDa 		No 0
ESRRB-006
ENSP00000451658
ENST00000556177
O95718 [Direct mapping]
Steroid hormone receptor ERR2
Show all
Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 433 aa
48.1 kDa 		No 0
ESRRB-201
ENSP00000422488
ENST00000509242
O95718 [Direct mapping]
Steroid hormone receptor ERR2
Show all
Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001701 [in utero embryonic development]
GO:0001831 [trophectodermal cellular morphogenesis]
GO:0001834 [trophectodermal cell proliferation]
GO:0001892 [embryonic placenta development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019827 [stem cell population maintenance]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 508 aa
56.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.