We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
COQ6 (HGNC Symbol)
Synonyms
CGI-10
Description
Coenzyme Q6 monooxygenase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005794 [Golgi apparatus] GO:0006744 [ubiquinone biosynthetic process] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0042995 [cell projection] GO:0044281 [small molecule metabolic process] GO:0044550 [secondary metabolite biosynthetic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005794 [Golgi apparatus] GO:0006744 [ubiquinone biosynthetic process] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0042995 [cell projection] GO:0044281 [small molecule metabolic process] GO:0044550 [secondary metabolite biosynthetic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity] GO:0006744 [ubiquinone biosynthetic process] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0044550 [secondary metabolite biosynthetic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity] GO:0006744 [ubiquinone biosynthetic process] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0044550 [secondary metabolite biosynthetic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding]