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RHOQ

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GENERAL INFORMATION

Gene name

 RHOQ

Gene description

 Ras homolog family member Q

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA044938
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & vesicles.

Main location

 Vesicles (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044938 SH-SY5Y Vesicles Intensity
HPA044938 U-2 OS Vesicles
Cytosol

GENE INFORMATION

Gene name

 RHOQ (HGNC Symbol)

Synonyms

 ARHQ, RASL7A, TC10

Description

 Ras homolog family member Q (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 46541806 - 46583121

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119729 (version 83.38)

Entrez gene

 23433

UniProt

 P17081 (UniProt - Evidence at protein level)

neXtProt

 NX_P17081

Antibodypedia

 RHOQ antibodies

PROTEIN BROWSER
RHOQ-001
RHOQ-002
RHOQ-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RHOQ-001
ENSP00000238738
ENST00000238738
P17081 [Direct mapping]
Rho-related GTP-binding protein RhoQ
V9HWD0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 42; Ras homolog gene family, member Q, isoform CRA_d
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032427 [GBD domain binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046039 [GTP metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051491 [positive regulation of filopodium assembly]
GO:0070062 [extracellular exosome]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
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 205 aa
22.7 kDa 		No 0
RHOQ-002
ENSP00000428006
ENST00000482449
E5RFZ3 [Direct mapping]
Rho-related GTP-binding protein RhoQ
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
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 75 aa
8.6 kDa 		Yes 0
RHOQ-201
ENSP00000484856
ENST00000616091
A0A0C4DH03 [Direct mapping]
Rho-related GTP-binding protein RhoQ
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 213 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.