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FKBP1B

GENERAL INFORMATION

Gene name

 FKBP1B

Gene description

 FK506 binding protein 1B, 12.6 kDa

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expresssion in several tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA051798
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FKBP1B (HGNC Symbol)

Synonyms

 FKBP12.6, FKBP1L, FKBP9, OTK4, PPIase

Description

 FK506 binding protein 1B, 12.6 kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 24049701 - 24063681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119782 (version 83.38)

Entrez gene

 2281

UniProt

 P68106 (UniProt - Evidence at protein level)

neXtProt

 NX_P68106

Antibodypedia

 FKBP1B antibodies

PROTEIN BROWSER
FKBP1B-001
FKBP1B-002
FKBP1B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP1B-001
ENSP00000370373
ENST00000380986
P68106 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP1B
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002027 [regulation of heart rate]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005219 [ryanodine-sensitive calcium-release channel activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006939 [smooth muscle contraction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009749 [response to glucose]
GO:0010033 [response to organic substance]
GO:0010459 [negative regulation of heart rate]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019227 [neuronal action potential propagation]
GO:0019855 [calcium channel inhibitor activity]
GO:0022417 [protein maturation by protein folding]
GO:0030018 [Z disc]
GO:0030073 [insulin secretion]
GO:0030551 [cyclic nucleotide binding]
GO:0032513 [negative regulation of protein phosphatase type 2B activity]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033197 [response to vitamin E]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042026 [protein refolding]
GO:0042098 [T cell proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044325 [ion channel binding]
GO:0048680 [positive regulation of axon regeneration]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051280 [negative regulation of release of sequestered calcium ion into cytosol]
GO:0051284 [positive regulation of sequestering of calcium ion]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051775 [response to redox state]
GO:0055085 [transmembrane transport]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061077 [chaperone-mediated protein folding]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070588 [calcium ion transmembrane transport]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 108 aa
11.8 kDa 		No 0
FKBP1B-002
ENSP00000370379
ENST00000380991
P68106 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP1B
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005102 [receptor binding]
GO:0005219 [ryanodine-sensitive calcium-release channel activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0010459 [negative regulation of heart rate]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0019855 [calcium channel inhibitor activity]
GO:0022417 [protein maturation by protein folding]
GO:0030018 [Z disc]
GO:0032513 [negative regulation of protein phosphatase type 2B activity]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042026 [protein refolding]
GO:0044325 [ion channel binding]
GO:0051280 [negative regulation of release of sequestered calcium ion into cytosol]
GO:0051284 [positive regulation of sequestering of calcium ion]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051775 [response to redox state]
GO:0055085 [transmembrane transport]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061077 [chaperone-mediated protein folding]
GO:0070588 [calcium ion transmembrane transport]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 80 aa
8.8 kDa 		No 0
FKBP1B-006
ENSP00000406593
ENST00000452109
F8W6G9 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 79 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.