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A majority of malignant tissues displayed weak to moderate cytoplasmic and membranous immunoreactivity. Several colorectal cancers were strongly positive, while most malignant gliomas, lymphomas and melanomas were negative.
Among malignant cells, moderate to strong membranous immunoreactivity was observed in a majority of cells. Malignant melanomas, lymphomas and gliomas were in general negative.
Colorectal, prostate, ovarian, endometrial, thyroid and lung cancers along with a few cases of breast and skin cancers exhibited strong membranous and cytoplasmic positivity. Remaining malignant tissues were negative.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]