Tissue expression of SLC17A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC17A5
Gene description	Solute carrier family 17 (acidic sugar transporter), member 5
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (parathyroid gland)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC17A5 (HGNC Symbol)
Synonyms	AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Description	Solute carrier family 17 (acidic sugar transporter), member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q13
Chromosome location (bp)	73593379 - 73654155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119899 (version 83.38)
Entrez gene	26503
UniProt	Q9NRA2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRA2
Antibodypedia	SLC17A5 antibodies

PROTEIN BROWSER

SLC17A5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC17A5-001 ENSP00000348019 ENST00000355773	Q9NRA2 [Direct mapping] Sialin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005351 [sugar:proton symporter activity] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0006865 [amino acid transport] GO:0015136 [sialic acid transmembrane transporter activity] GO:0015739 [sialic acid transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] Show all	495 aa 54.6 kDa	No	>9