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NKX2-3

GENERAL INFORMATION

Gene name

 NKX2-3

Gene description

 NK2 homeobox 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen, small intestine)
GTEx:Group enriched (spleen, colon, small intestine, salivary gland)
FANTOM5:Tissue enhanced (spleen, small intestine, appendix, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047561
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, colon, small intestine, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine, appendix, colon)

GENE INFORMATION

Gene name

 NKX2-3 (HGNC Symbol)

Synonyms

 CSX3, NKX2.3, NKX2C, NKX4-3

Description

 NK2 homeobox 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 99532933 - 99536524

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119919 (version 83.38)

Entrez gene

 159296

UniProt

 Q8TAU0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8TAU0

Antibodypedia

 NKX2-3 antibodies

PROTEIN BROWSER
NKX2-3-001
NKX2-3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX2-3-001
ENSP00000342828
ENST00000344586
Q8TAU0 [Direct mapping]
Homeobox protein Nkx-2.3
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
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GO:0001776 [leukocyte homeostasis]
GO:0002317 [plasma cell differentiation]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006641 [triglyceride metabolic process]
GO:0006955 [immune response]
GO:0008150 [biological_process]
GO:0009791 [post-embryonic development]
GO:0022612 [gland morphogenesis]
GO:0030183 [B cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0042127 [regulation of cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043367 [CD4-positive, alpha-beta T cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048535 [lymph node development]
GO:0048536 [spleen development]
GO:0048537 [mucosal-associated lymphoid tissue development]
GO:0048541 [Peyer's patch development]
GO:0048565 [digestive tract development]
GO:0048621 [post-embryonic digestive tract morphogenesis]
GO:0050900 [leukocyte migration]
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 364 aa
38.4 kDa 		No 0
NKX2-3-201
ENSP00000479692
ENST00000622383
A0A087WVU3 [Direct mapping]
Homeobox protein Nkx-2.3
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 296 aa
32.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.