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Several hepatocellular carcinomas displayed moderate to strong cytoplasmic positivity. Malignant melanomas along with a few cases of endometrial, colorectal, breast and urothelial cancers showed weak to moderate staining. Remaining malignant cells were negative.
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]