Expression of TCTN3 in cancer - Summary

CANCER ATLAS

Gene description

Tectonic family member 3

Protein class

Disease related genes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026987

GENE INFORMATION
Gene name	TCTN3 (HGNC Symbol)
Synonyms	C10orf61, DKFZP564D116, JBTS18, TECT3
Description	Tectonic family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	95663396 - 95694143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119977 (version 83.38)
Entrez gene	26123
UniProt	Q6NUS6 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NUS6
Antibodypedia	TCTN3 antibodies

PROTEIN BROWSER

TCTN3-001	TCTN3-007	TCTN3-009	TCTN3-010	TCTN3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCTN3-001 ENSP00000265993 ENST00000265993	A0A0C4DFN5 [Direct mapping] Chromosome 10 open reading frame 61; Tectonic-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	625 aa 68 kDa	No	1
TCTN3-007 ENSP00000360253 ENST00000371209	Q6NUS6 [Direct mapping] Tectonic-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0060170 [ciliary membrane] GO:0060271 [cilium morphogenesis] GO:0070062 [extracellular exosome] Show all	443 aa 48 kDa	Yes	0
TCTN3-009 ENSP00000360261 ENST00000371217	Q6NUS6 [Direct mapping] Tectonic-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0060170 [ciliary membrane] GO:0060271 [cilium morphogenesis] GO:0070062 [extracellular exosome] Show all	607 aa 66.2 kDa	Yes	1
TCTN3-010 ENSP00000387567 ENST00000430368	Q6NUS6 [Direct mapping] Tectonic-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0060170 [ciliary membrane] GO:0060271 [cilium morphogenesis] GO:0070062 [extracellular exosome] Show all	459 aa 50.3 kDa	Yes	1
TCTN3-201 ENSP00000483364 ENST00000614499	Q6NUS6 [Direct mapping] Tectonic-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0060170 [ciliary membrane] GO:0060271 [cilium morphogenesis] GO:0070062 [extracellular exosome] Show all	607 aa 66.2 kDa	Yes	1