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Ovarian cancers and melanomas along with several cases of skin, pancreatic, renal, gastric, colorectal and liver cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were in general negative.
GENE INFORMATION
Gene name
WDR11 (HGNC Symbol)
Synonyms
BRWD2, DR11, FLJ10506, HH14, KIAA1351, WDR15
Description
WD repeat domain 11 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
