Cell atlas - CPN1 - The Human Protein Atlas

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CPN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CPN1
Gene description	Carboxypeptidase N, polypeptide 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Cell line enriched (SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040323
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040323	CACO-2	Nucleus
	HPA040323	CACO-2	Nucleoli
	HPA040323	Hep G2	Nucleus
	HPA040323	U-2 OS	No staining

GENE INFORMATION
Gene name	CPN1
Synonyms
Description	Carboxypeptidase N, polypeptide 1 (HGNC Symbol)
Entrez gene summary	Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.2
Chromosome location (bp)	100042193 - 100081877
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120054 (version 83.38)
Entrez gene	1369
UniProt	P15169 (UniProt - Evidence at protein level)
neXtProt	NX_P15169
Antibodypedia	CPN1 antibodies

PROTEIN BROWSER

CPN1-001	CPN1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPN1-001 ENSP00000359446 ENST00000370418	P15169 [Direct mapping] Carboxypeptidase N catalytic chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0010815 [bradykinin catabolic process] GO:0051384 [response to glucocorticoid] Show all	458 aa 52.3 kDa	Yes	0
CPN1-003 ENSP00000410895 ENST00000441382	B1AP58 [Direct mapping] Carboxypeptidase N catalytic chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	204 aa 22.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.