Tissue expression of SFRP5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SFRP5
Gene description	Secreted frizzled-related protein 5
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum, pancreas, small intestine)
GTEx:	Tissue enhanced (pancreas)
FANTOM5:	Tissue enhanced (retina, gallbladder)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum, pancreas, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, gallbladder)

GENE INFORMATION
Gene name	SFRP5 (HGNC Symbol)
Synonyms	SARP3
Description	Secreted frizzled-related protein 5 (HGNC Symbol)
Entrez gene summary	Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.2
Chromosome location (bp)	97766751 - 97771952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120057 (version 83.38)
Entrez gene	6425
UniProt	Q5T4F7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5T4F7
Antibodypedia	SFRP5 antibodies

PROTEIN BROWSER

SFRP5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFRP5-001 ENSP00000266066 ENST00000266066	Q5T4F7 [Direct mapping] Secreted frizzled-related protein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0008285 [negative regulation of cell proliferation] GO:0009653 [anatomical structure morphogenesis] GO:0017147 [Wnt-protein binding] GO:0030154 [cell differentiation] GO:0035414 [negative regulation of catenin import into nucleus] GO:0035567 [non-canonical Wnt signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060070 [canonical Wnt signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000057 [negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis] Show all	317 aa 35.6 kDa	Yes	0