Cell atlas - HOXB8 - The Human Protein Atlas

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HOXB8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HOXB8
Gene description	Homeobox B8
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEK 293, EFO-21, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA075905
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, EFO-21, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075905	HEK 293	Nucleoplasm

GENE INFORMATION
Gene name	HOXB8 (HGNC Symbol)
Synonyms	HOX2, HOX2D
Description	Homeobox B8 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48611377 - 48614939
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120068 (version 83.38)
Entrez gene	3218
UniProt	P17481 (UniProt - Evidence at transcript level)
neXtProt	NX_P17481
Antibodypedia	HOXB8 antibodies

PROTEIN BROWSER

HOXB8-001	HOXB8-002	HOXB8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXB8-001 ENSP00000239144 ENST00000239144	P17481 [Direct mapping] Homeobox protein Hox-B8 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007625 [grooming behavior] GO:0008344 [adult locomotory behavior] GO:0009952 [anterior/posterior pattern specification] GO:0019233 [sensory perception of pain] GO:0021516 [dorsal spinal cord development] GO:0043565 [sequence-specific DNA binding] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048705 [skeletal system morphogenesis] Show all	243 aa 27.6 kDa	No	0
HOXB8-002 ENSP00000460659 ENST00000576562	I3L3R1 [Direct mapping] Homeobox B8, isoform CRA_a; Homeobox protein Hox-B8 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	242 aa 27.5 kDa	No	0
HOXB8-003 ENSP00000460254 ENST00000498634	I3L383 [Direct mapping] Homeobox protein Hox-B8 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	128 aa 14.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.