Fields »
ABOUT
HELP
BLOG
GRIA2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 GRIA2

Gene description

 Glutamate receptor, ionotropic, AMPA 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GRIA2 (HGNC Symbol)

Synonyms

 GluA2, GLUR2, GLURB

Description

 Glutamate receptor, ionotropic, AMPA 2 (HGNC Symbol)

Entrez gene summary

 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 157204182 - 157366075

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120251 (version 83.38)

Entrez gene

 2891

UniProt

 P42262 (UniProt - Evidence at protein level)

neXtProt

 NX_P42262

Antibodypedia

 GRIA2 antibodies

PROTEIN BROWSER
GRIA2-001
GRIA2-002
GRIA2-004
GRIA2-005
GRIA2-008
GRIA2-009
GRIA2-010
GRIA2-011
GRIA2-012
GRIA2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRIA2-001
ENSP00000296526
ENST00000296526
P42262 [Direct mapping]
Glutamate receptor 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0097060 [synaptic membrane]
Show all
 883 aa
98.9 kDa 		Yes 3
GRIA2-002
ENSP00000264426
ENST00000264426
P42262 [Direct mapping]
Glutamate receptor 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 883 aa
98.8 kDa 		Yes 3
GRIA2-004
ENSP00000377403
ENST00000393815
P42262 [Direct mapping]
Glutamate receptor 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 836 aa
93.8 kDa 		No 3
GRIA2-005
ENSP00000426845
ENST00000507898
P42262 [Direct mapping]
Glutamate receptor 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 836 aa
93.8 kDa 		No 3
GRIA2-008
ENSP00000423988
ENST00000512774
D6RBV7 [Direct mapping]
Glutamate receptor 2
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 48 aa
5.3 kDa 		Yes 0
GRIA2-009
ENSP00000425217
ENST00000509417
D6RDX5 [Direct mapping]
Glutamate receptor 2
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 125 aa
13.8 kDa 		Yes 0
GRIA2-010
ENSP00000426513
ENST00000506284
D6RFM6 [Direct mapping]
Glutamate receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 57 aa
6.4 kDa 		No 0
GRIA2-011
ENSP00000422038
ENST00000505888
D6R9Z0 [Direct mapping]
Glutamate receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 145 aa
16.4 kDa 		No 0
GRIA2-012
ENSP00000423229
ENST00000510854
H0Y972 [Direct mapping]
Glutamate receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 214 aa
23.6 kDa 		No 1
GRIA2-014
ENSP00000426784
ENST00000503437
D6REK8 [Direct mapping]
Glutamate receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0030425 [dendrite]
GO:0032281 [AMPA glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
Show all
 105 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.