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Many cases of hepatocellular carcinomas, prostate and endometrial cancers showed moderate cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
MAGEB4 (HGNC Symbol)
Synonyms
CT3.6, MGC33144
Description
Melanoma antigen family B4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]
