Expression of MRPS14 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein S14

Protein class

Predicted secreted proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051087

GENE INFORMATION
Gene name	MRPS14 (HGNC Symbol)
Synonyms	HSMRPS14
Description	Mitochondrial ribosomal protein S14 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	175010789 - 175023425
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120333 (version 83.38)
Entrez gene	63931
UniProt	O60783 (UniProt - Evidence at protein level)
neXtProt	NX_O60783
Antibodypedia	MRPS14 antibodies

PROTEIN BROWSER

MRPS14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS14-001 ENSP00000420714 ENST00000476371	O60783 [Direct mapping] 28S ribosomal protein S14, mitochondrial Show all	Ribosomal proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005763 [mitochondrial small ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	128 aa 15.1 kDa	Yes	0