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Cancer tissues showed weak nuclear and occasional cytoplasmic immunoreactivity. A few cases of ovarian, thyroid, testicular and urothelial cancers expressed moderate staining. Several cases of carcinoids, lymphomas, endometrial and lung cancers were negative.
SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]